Seeber M., Michel C.
A number of serious diseases, i.e. Parkinson’s, Tourette syndrome and obsessive-compulsive disorders (OCD) are directly associated with subcortical regions. Deep brain stimulation (DBS) is applied as a therapy for severe cases suffering from these diseases. While subcortical areas are known to play an important role in mediating interactions in large-scale networks, it is less clear how their dysfunction affect certain diseases. Furthermore, it is an ongoing discussion how DBS influences subcortical-cortical networks dynamics leading to the treatment’s outcome. In order to study electrophysiological dynamics in subcortical regions, implanted electrodes in these areas are needed. This neurosurgery is naturally only justifiable and possible in the framework of deep brain stimulation therapy, which restricts investigating subcortical dynamics in humans to a few case studies.