Category Archive

December 2022

RESEARCH

Weier Wan, Rajkumar Kubendran, Clemens Schaefer, S. Burc Eryilmaz, Wenqiang Zhang, Dabin Wu, Stephen Deiss, Priyanka Raina, He Qian, Bin Gao, Siddharth Joshi, Huaqiang Wu, H.-S. Philip Wong, Gert Cauwenberghs

AI-powered edge devices such as smart wearables, smart home appliances, and smart Internet-of-things (IoT) sensors are already pervasive in our lives. Yet, most of these devices are only smart when they are connected to the internet. Under limited battery capacity and cost budget, local chipsets inside these devices are only capable of relatively simple data processing, while the more computationally demanding AI tasks are offloaded to the remote cloud.

December 2022

RESEARCH

Anna W. Roe

Scientists and engineers have long drawn inspiration from the biological world to understand how architecture gives rise to function. To learn how to fly, study the architecture of bird and insect wings [1]. To build a master swimmer, study the architecture of fish and amphibian neuromuscular oscillators [2]. In the same vein, to understand intelligence, study the architecture of human and nonhuman primate brains. This last endeavor (Neuromorphics or Neuromorphic Computing), has generated ‘smart machines’ that can mimic perception and motor behavior, and have been modelled on the currency of brain function, neuronal spike firing [3,4]. Such approaches have driven the development of new computing architectures that overcome von Neumann bottlenecks, GPUs that accelerate via mass parallelism, in-memory processors, and implementation of attractor networks and finite state machines [5]. Year-by-year, we see accelerations in benchmark performance, expansion of hardware and software technology, and computational deep neural network sophistication [6]. However, despite these breathtaking advances, many of the basic functions of intelligent systems–rapid and efficient memory access, behaviorally targeted resource allocation, on-the-fly response to ever-changing contexts, and energy efficient computation–remain fundamentally out of reach.

December 2022

OPINION

Biqiu Tang, Hui Sun, Naici Liu, Youjin Zhao, Chengming Yang, Senhao Liu, Qiyong Gong, Wenjing Zhang, Su Lui

With the increase of the pace of life, work pressure, work-family conflict, social changes and emergencies, the prevalence of mental disorders are increasing, which contributed to a large proportion of the global disease burden. At present, the diagnosis and classifications of mental disorders in psychiatry has been relying on psychological and behavioral observations, while heterogeneity within psychiatric syndromes such as depression and psychosis in genetics, neurobiology and treatment outcomes was widely demonstrated in such way. When diagnostic labels do not map precisely onto either biology or treatment outcome, it is challenging to conduct translational neuroscience research to extend the understanding of pathogenesis and develop treatments that will target alterations in specific patients for personalized treatment. In addition, since current diagnosis requires that the defining behavioral features are already present, it is difficult to develop targeted prevention-based interventions.

December 2022

RESEARCH

Wei Liu, Bao-Liang Lu

Emotions, especially facial expressions, used to be thought of as universal all around the world: we would cry when we are sad, and we would smile when we are happy. However, you might have experienced that you do not laugh after hearing a foreign joke realizing that the joke has distinct cultural backgrounds. Emotions, therefore, seem to have both universal and culturally variable components. Understanding the relationship between cultures and emotions can help us know whether emotions affect physical health in the same way across various cultures and inform us about the effectiveness of mental health interventions for patients with different cultural backgrounds. In addition, from the aspect of affective computing, a deep comprehension of cultural influences on emotions can help us build emotion recognition models for generalizing to people around the world.

December 2022

RESEARCH

Ye Tian, Cunkai Zhou, Kuikui Zhang, Huiran Yang, Zhaohan Chen, Zhitao Zhou, Xiaoling Wei, Tiger H. Tao, Liuyang Sun

Implantable flexible neural probes have been demonstrated bridging the mechanical mismatch between invasive probes and brain tissues, minimizing footprint in brain, and chronic biocompatibility [1]. However, conventional needle-shaped flexible neural probes reported before have recording sites distributed vertically along a relatively narrow shank [2], which limits the lateral range in which the probes may record neural signals. Although designs with more probe shanks expand the lateral detectable range, the high implantation density reflects in increased tissue damage and surgery complexity. In this work, we developed a flexible neural probe by novel Christmas-tree structure, which has branches that are foldable along the shank by temporary encapsulation before implantation and self-stretchable after the encapsulation dissolves after implantation. The probe we developed affords increased lateral sensing range without causing extra brain tissue damage.

Communicated by Distinguished Professor Chin-Teng Lin 

RESEARCH

May 2022

Chin-Teng Lin and Alka Rachel John

Humans are easily overwhelmed with tasks that push them beyond their capabilities. Despite their remarkable resilience to diverse working conditions, the work environment must be adapted to afford comfortable interactions with human operator abilities. Modern work environments position human operators at a supervisory level where they have extensive interactions with technology and must integrate multiple streams of information, demanding more cognitive resources and resulting in a higher workload in the human operators. 

May 2022

RESEARCH

Jihun Lee, Ahhyoung Lee, Vincent Leung, Farah Laiwalla, Arto Nurmikko

The concept of brain circuits computing as an extended network, composed of billions of neurons represents a contemporary view which is exploited in research of brain-machine interfaces (BMI). Population dynamics recorded from ensembles of neurons have been dominated by intracortical silicon-based microelectrode arrays (MEA), monolithic ‘beds of needles’, wired to external signal processing electronics. The work has deepened our understanding of underlying functional principles especially of the motor cortex as a network, leading to first clinical trials of human BMIs. The importance of computational techniques in neural decoding in this highly undersampled circumstance is demonstrated in the example study: e.g. recent work by the Stanford group where pattern recognition of spiking neural population has demonstrated a BMI hand writing-to-text capability. A forward-looking question is about the type of neural recording device technologies which are scalable and able to access a much larger number of neurons for decoding complex motor, sensory, and perhaps even cognitive tasks.

May 2022

RESEARCH

Abraham Akinin, Jeremy M. Ford, Jiajia Wu, Chul Kim, Hiren D. Thacker, Patrick P. Mercier, and Gert Cauwenberghs.

Sight is integral to our ability to perceive and interact with the world. The visual system captures information in such detail that it encompasses almost the entire sensory input bandwidth of the brain. And yet, millions of patients are afflicted with blindness requiring assistive technologies and community accommodation.  A growing number of these cases are caused by diseases that result neural degeneration of photoreceptor cells in the retina such as Age-related Macular Degeneration.  Implantable prosthetics to electrically stimulate the retina and restore vision are an active area of academic research and commercialization efforts.  Unfortunately, considerable efforts have not produced a significant quality of life enhancement parallel to the astounding results of cochlear implants to restore hearing. To get there, novel approaches are needed to overcome the field’s main challenges: limited resolution and obtrusive packaging. 

May 2022

RESEARCH

Kuanming Yao, Guangyao Zhao, Xinge Yu

Distinguished from conventional rigid electronics, soft electronics is becoming a novel platform for next-generation biomedical instrumentations. With advanced materials, mechanics, and structural design, soft electronics could be realized in thin, light-weighted formats and thus can be worn on or implanted in human body, and may excel in great stretchability and conformal attachment with skin or tissue, which ensures continuous and precise healthcare monitoring or therapies. Our group focuses on exploring the novel soft electronics for the applications in various fields of biomedical applications, including motion and mechanical sensing, wearable energy harvesting, dynamic temperature sensing, sweat sensing, and closed-loop human-machine interface.

May 2022

RESEARCH

Adam Li, Chester Huynh, Zachary Fitzgerald, Iahn Cajigas, Damian Brusko, Jonathan Jagid, Angel Claudio, Andres Kanner, Jennifer Hopp, Stephanie Chen, Jennifer Haagensen, Emily Johnson, William Anderson, Nathan Crone, Sara Inati, Kareem Zaghloul, Juan Bulacio, Jorge Gonzalez-Martinez, and Sridevi V. Sarma

Over 3.4 million people in the US have epilepsy and 30% of these patients have drug-resistant epilepsy (DRE), where they do not respond to medication. DRE patients are burdened by epilepsy-related disabilities and frequently hospitalized constituting around $13 billion dollars annually spent for treating epilepsy patients in the USA. Successful surgical treatment necessitates complete elimination of the brain region(s) known as the seizure onset zone (SOZ). Between 30%-70% of patients continue to have seizures 6 months after treatment due to mislocalization of the SOZ. We developed neural fragility, an electroencephalogram (EEG) marker for the SOZ, and validated it in a retrospective study of 91 patients predicting surgical outcomes using neural fragility conditioned on the clinically labeled SOZ. Fragility predicted 43 out of the 47 surgical failures correctly and had an overall accuracy of 76%, compared to the clinical accuracy of 48% (successful outcomes). Neural fragility outperformed 20 other EEG features on the same set of cross-validation samples suggesting it as a potential EEG biomarker for the SOZ.