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Multimodal Imaging in Understanding Brain Diseases

The advances in neuroimaging in the last decades have bridged the translational gap, and enabled our understanding of the brain under physiological and disease conditions. Multiscale and multimodal imaging such as positron emission tomography, magnetic resonance imaging, optoacoustic and fluorescence imaging have provided molecular, structural, and functional insights at cellular, circuit, and whole brain levels.

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Modeling the Representation of Object Boundary Contours in Human fMRI Data

The human visual system consists of a hierarchy of areas, each of which represents different features of the visual world. Recent studies have revealed that most brain areas—and even many individual neurons—represent information about multiple visual features. Thus, a complete model of the brain must specify the relative importance of multiple visual features across the visual hierarchy. This talk will …

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Neurophotonic Systems: From Flexible Polymer Implants to in situ Ultrasonically-driven Light Guides

Understanding the neural basis of brain function and dysfunction may inform the design of effective therapeutic interventions for brain disorders and mental illnesses. Optical techniques have been recently developed for structural and functional imaging as well as targeted stimulation of neural circuits. One of the challenges of optical modality is light delivery deep into the brain tissue in a non-invasive …

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Fiberless Optoelectrodes for Selective Optical Neuromodulation at Cellular Resolution

This talk will review the evolution of Michigan neural probe technologies toward scaling up the number of recording sites, enhancing the recording reliability, and introducing multi-modalities in neural interface including optogenetics. Modular system integration and compact 3D packaging approaches have been explored to realize high-density neural probe arrays for recording of more than 1,000 channels simultaneously.

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Data-Driven Modeling of Brain Circuits Based on a Systematic Experimental Platform

The Mindscope project at the Allen Institute aims to elucidate mechanisms underlying cortical function in the mouse, focusing on the visual system. This involves concerted efforts of multiple teams characterizing cell types, connectivity, and neuronal activity in behaving animals. An integral part of these efforts is the construction of models of the cortical tissue and cortical computations.