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Closed-Loop Neurotechnologies

Understanding the brain and other areas of the nervous system has always been challenging. While research has led to a better understanding at the cellular/neuron level, a clear picture of how those neurons work together as part of a larger system of neural circuits has been more evasive.  Closed-loop neurotechnologies, an expanding area of study, are advancing the reading and …

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Neurotherapy: Treating Disorders by Retraining the Brain

There still exists a number of psychiatric, neurologic, and other brain-related disorders without highly effective treatment. Could neurotherapy hold the key to treating such diseases? Neurotherapy, while still very early in its development, has already shown efficacy in altering brain function to provide relief to patients suffering from a range of disorders. This article will discuss the current state of …

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Neurotechnologies: The Next Technology Frontier

For millennia, the human brain has been a largely unexplored frontier. Relative to the whole of human history, studying, understanding, and influencing human thought and consciousness is a radically new endeavor. Only in the twenty-first century has science truly begun to progress far enough into the field of neuroscience for effective neurotechnologies to begin to take shape.  The implications of …

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Brain Machine Interfaces: Concept to Clinic

Over the last two decades neural prostheses that aim to restore lost motor function have moved quickly from concept to laboratory development and clinical demonstration. In parallel, advances in neural interfacing technologies poised to broaden clinical application of these prostheses are actively in development in both academic and industry settings.

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Optimizing Control and Learning in Neural Interfaces

Direct interfaces with the brain provide exciting new ways to restore and repair neurological function. For instance, motor Brain-Machine Interfaces (BMIs) can bypass a paralyzed person’s injury by repurposing intact portions of their brain to control movements. Recent work shows that BMIs do not simply “decode” subjects’ intentions—they create new systems subjects learn to control. To improve BMI performance and …

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A Large-scale Standardized Physiological Pipeline Reveals Functional Organization of the Mouse Visual Cortex

An important open question in visual neuroscience is how visual information is represented in the cortex. Important results characterized neural coding by assessing the responses to artificial stimuli, with the assumption that responses to gratings, for example, capture the key features of neural responses, and deviations, such as extra-classical effects, are relatively minor. The failure of these responses to have …

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Multimodal Imaging in Understanding Brain Diseases

The advances in neuroimaging in the last decades have bridged the translational gap, and enabled our understanding of the brain under physiological and disease conditions. Multiscale and multimodal imaging such as positron emission tomography, magnetic resonance imaging, optoacoustic and fluorescence imaging have provided molecular, structural, and functional insights at cellular, circuit, and whole brain levels.

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Modeling the Representation of Object Boundary Contours in Human fMRI Data

The human visual system consists of a hierarchy of areas, each of which represents different features of the visual world. Recent studies have revealed that most brain areas—and even many individual neurons—represent information about multiple visual features. Thus, a complete model of the brain must specify the relative importance of multiple visual features across the visual hierarchy. This talk will …

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Neurophotonic Systems: From Flexible Polymer Implants to in situ Ultrasonically-driven Light Guides

Understanding the neural basis of brain function and dysfunction may inform the design of effective therapeutic interventions for brain disorders and mental illnesses. Optical techniques have been recently developed for structural and functional imaging as well as targeted stimulation of neural circuits. One of the challenges of optical modality is light delivery deep into the brain tissue in a non-invasive …

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Fiberless Optoelectrodes for Selective Optical Neuromodulation at Cellular Resolution

This talk will review the evolution of Michigan neural probe technologies toward scaling up the number of recording sites, enhancing the recording reliability, and introducing multi-modalities in neural interface including optogenetics. Modular system integration and compact 3D packaging approaches have been explored to realize high-density neural probe arrays for recording of more than 1,000 channels simultaneously.